Our key goal is to uncover the molecular basis of epigenetic memory.
We focus on studying the impact of diet on DNA in the body’s cells, as diet is a primary environmental signal that significantly affects our health and aging process.
Our research concentrates on immune cells, particularly those present in the blood. Through intervention studies (such as vitamin D supplementation during the winter), we analyze blood samples from participants to assess how micro- and macronutrients influence the epigenome of immune cells, such as monocytes and T lymphocytes.
We also explore the relationship between patients’ reactivity to key dietary components and the development of chronic diseases, including cancers, diabetes, and autoimmune disorders. To better understand these connections, we study individuals with multiple sclerosis and Fanconi anemia.
Our research employs advanced techniques, including RNA-seq for transcriptome analysis and ATAC-seq for studying the epigenome. We also analyze DNA methylation at the whole-genome level, histone modifications, and transcription factor binding. Our studies include epigenetic changes in human hematopoietic stem and progenitor cells, particularly under the influence of vitamin D.
We collaborate with international partners, testing synthetic compounds such as vitamin D analogs, which may have practical applications.