Our work is concentrated on understanding the cellular and molecular mechanisms underlyingskin wound healing , including the mechanisms responsible for directing this process: scar-forming (repair) versus scarless (regeneration), as well as analyzing factors influencing its variability, such as diet, age, and sex.
We investigate how the transcription factor Foxn1, hypoxia, antioxidant mechanisms, and intradermal adipocytes affect skin homeostasis and the wound healing process. We utilize adipose tissue stem cells and are developing a cell model of diabetic foot to improve and/or enhance the healing of skin wounds.
Our research is conducted using in vivo experimental models (mice, domestic pigs, human skin samples) and in vitro cultures of skin cells: keratinocytes and dermal fibroblasts, cultures of pig adipose tissue stem cells, and cultures of human vascular endothelial cells.
We employ methods of molecular biology and genetic engineering, protein detection methods, omics studies, and imaging techniques at the cellular and tissue levels.
The research conducted by our team is basic sciences; however, its results may have clinical and practical applications, including the development of new therapeutic tools to support skin wound healing.
